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Description

Comparison of methylation episignatures in KMT2B - and KMT2D -related human disorders

DOX is known to interact with DNA by intercalation, causing inhibition of macromolecular biosynthesis and to inhibit the role of the enzyme topoisomerase II during transcription and replication 16

[0338] In some embodiments, a pharmaceutical composition according to the present disclosure contains at least about 0.5 pg, 1 pg, 5 pg, 10 pg, 100 pg, 500 pg, or 1000 pg of encapsulated mRNA